Endocrine Abstracts

Introduction: Delayed diagnosis of secondary hypertension, notably primary aldosteronism, challenges healthcare. Inconsistent guideline adherence hampers detection rates and diagnostic uniformity, emphasizing the imperative for improved diagnostic strategies in identifying primary hyperaldosteronism. Our study directly addresses this critical gap in clinical care, underscoring the need for enhanced diagnostics in patients undergoing investigation for secondary endocrine hypert...

Background: Avascular necrosis of the femoral head (AVNFH) is a disorder caused mainly by chronic glucocorticoid use. Systemic corticosteroid (CS) therapy was widely used in patients with mild or moderate SARS-CoV 2 infection despite lack of clinical benefits. However, emerging evidence suggests that COVID-19 infection can cause long-term effects, affecting different body systems, known as ‘long COVID-19’1. One such sequela is AVNFH, although the link betw...

Introduction: While most of neuroendocrine tumors (NETs) primary sites are discovered, NETs of unknown primary are not entirely uncommon in the clinical setting. The primary site is a significant factor in terms of overall prognosis. The aim is to determine whether NETs of unknown primary site location (NET-USs) have more aggressive behavior than those with a known primary location. Matherials and Methods: We retrospectively studied 50 consecutive patien...

Introduction: The MEN1 syndrome is caused by inactivating mutations of MEN1, a tumor suppressor gene encoding menin. A sporadic presentation is relatively rare (8-14%) and could be due to de novo mutations.Aim: To present an MEN1 case diagnosed following a routine consultation for amenorrheaCase presentation: A 44-year-old female presented with secondary amenorrhea and a history of complicated renal lithiasis requiring rep...

Background: Acromegaly is characterized by increased prevalence of fragility vertebral fractures. Nonetheless, there are no clear recommendations for prevention of acromegalic osteopathy. Both bone mineral density (BMD) and trabecular bone score (TBS) lack clear evidence as prognostic factors for vertebral fractures (VF).Material and Methods: We performed an observational study on 31 acromegalic patients recruited prospectively. They were tested for alka...

Introduction: Somatotroph pituitary adenomas (PAs) represent 10-15% of all resected PAs, exhibiting immunohistochemical (IHC) positivity for GH (growth hormone) and PIT-1 transcription factor (TF). The histopathological (HP) and IHC variability of each PA influences the phenotype, radiological features, and therapy response.Materials and methods: The study included 33 patients with acromegaly, with men: women ratio of 17:16. The HP-IHC characteristics we...

Background: Acromegaly is a rare disorder caused by hypersecretion of growth-hormone (GH) and insulin-like growth factor (IGF-1), the underlying lesion being most frequently a pituitary adenoma. This disease is associated with a higher risk of malignancy. We describe the clinical and biochemical particularities in a series of patients with acromegaly and papillary thyroid carcinoma (PTC).Case study: Out of 311 acromegalic patients, five cases that associ...

Introduction: We describe a patient with Cushing’s disease caused by a pituitary macroadenoma treated by double transsphenoidal surgery, stereotactic radiosurgery and steroidogenesis inhibitors and also the challenging management of a patient with multiple comorbidities, including chronic leg ulcers, which are related to increased morbidity and health costs.Case report: In October 2019, a 67-year-old patient presented with intense headache, left tem...

Background: Higher anti-Müllerian hormone (AMH) values are associated with polycystic ovary syndrome (PCOS) and AMH is proposed as a marker of PCOS, however, the optimal diagnostic threshold is not yet defined.Aim: To study the significant correlations of AMH in PCOS and the accuracy and threshold of AMH for the PCOS diagnosis in Romania.Subjects and methods: Serum AMH, TT, LH, FSH, fasting glucose and insulin (Ins), HOMA-IR a...

Introduction: Zinc homeostasis is involved in numerous physiological and pathological conditions, ranging from type 1 and type 2 diabetes to memory impairment and cancer, and is determined by at least 28 genes, including 24 SLC (Solute Carrier) family members and 4 MTs (Metallothioneins). To explore the potential role of zinc homeostasis in MetS (metabolic syndrome) and IR (insulin resistance), we investigated 28...